Receptor tyrosine kinases (RTKs) constitutea family of transmembraneproteins that pivotally regulate essential cellular processes, includinggrowth, differentiation, and metabolism. Their aberrant activity is a well-established driver of cancer initiationand progression, positioning RTKs as key targets for anticancer drugdevelopment. Furthermore, the pursuitof effective kinase-inhibitor scaffolds remains a central theme inmedicinal chemistry. The gene discussed is NTRK1; the disease is cancer.