The hallmark pathological features of AD include accumulation of amyloid‐beta (Aβ) plaques, neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein, decrease of the neurotransmitter acetylcholine (ACh), neuroinflammation of the central nervous system, metabolic homeostasis disruption of metals, oxidative stress, β secretase‐1 (BACE‐1) activation, and widespread neuronal loss [16, 17]. Here, MAPT is linked to Alzheimer disease.