Among the key targets associated with AD are AChE, β‐site APP cleaving enzyme‐1, glycogen synthase kinase 3 beta (GSK‐3β), monoamine oxidases (MAOs), metal ions in the brain, NMDA receptor, 5‐hydroxytryptamine (5‐HT) receptors, the third subtype of histamine receptor, and phosphodiesterases [26, 53]. This evidence concerns the gene GSK3B and Alzheimer disease.