In this study, 17.7% of MAFLD patients had significant fibrosis, they were predominantly males, with older age, having a higher BMI, metabolic risk factors, elevated liver enzymes, FIB-4, but lower platelets and HDL, all these factors associated with obese-MAFLD, of which male gender, diabetes, hypertension, higher level of ALT, ALP, Hs-CRP, Uric acid, and lower level of platelets and HDL-cholesterol were predictors of significant fibrosis in obese-MAFLD. The gene discussed is CRP; the disease is Hypertension.