TLR4 and pulpitis: These results suggested that after pulpitis, TG neurons that dominated the pulpitis triggered the immune response via TLR4, further activating other TG neurons.32 High expression of CGRP was evident along the nerve fibers to the dental pulp tissue, which likely participated in the inflammation and pain responses.33 Cur treatment regulated neuroimmune responses by reducing the expression of TLR4 in the TG, exerting anti-inflammatory, analgesic, and neuroprotective effects.