Both scDb-hERG1-β1 and scDb-hERG1-β1-TRAIL penetrated into tumor masses as shown by (i) IHC staining with anti-His antibodies of the tumor masses collected at the end of the experiment (Fig. 6D) and (ii) photoacoustic imaging (PAI) using scDb-hERG1-β1 and scDb-hERG1-β1-TRAIL conjugated with ICG and injected locally in vivo (Fig. 6E). The gene discussed is TNFSF10; the disease is neoplasm.