Previous studies have demonstrated that proteins related to the Wnt/β-catenin signaling pathway (DKK-3, β-catenin, and c-MYC) are involved in the development of NPC, and that knockdown of FOXO3a promotes radioresistance in NPC through the Wnt/β-catenin signaling pathway (Pang et al., 2019; Luo et al., 2019). The gene discussed is DKK3; the disease is nasopharyngeal carcinoma.