Previous studies have demonstrated that the core genes of NPC-RSS, including SMARCA2, DMC1, CD9, PSG4, and KNG1, are associated with tumor radiosensitization to varying degrees (Zernickel et al., 2019; Xu et al., 2018b; Erovic et al., 2005; Jennrich et al., 2022; Xu et al., 2018a). This evidence concerns the gene NPC1 and neoplasm.