Gene Set Variation Analysis (GSVA) and Gene Set Enrichment Analysis (GSEA) indicated that the differential expression levels of SMARCA2, DMC1, CD9, PSG4, and KNG1 in the core of the NPC radiosensitivity signature (NPC-RSS) might influence various signaling pathways associated with disease progression, involving multiple biological processes such as DNA damage repair, cell death, immune regulation, cell proliferation, metabolism, tumor microenvironment regulation, and cell survival. The gene discussed is SMARCA2; the disease is nasopharyngeal carcinoma.