These findings underscore the AKT/mTOR signaling pathway as a pivotal intracellular route governed by Let‐7b‐5p in the regulation of HCC cell behaviors and confirm the role of Let‐7b‐5p in inhibiting HCC progression by regulating cell proliferation, migration, and apoptosis, and identify a potential new treatment target by blocking the AKT/mTOR signaling pathway. Here, AKT1 is linked to hepatocellular carcinoma.