MASP1 and Hepatic fibrosis: Although miR-122 binding to HCV viral RNA has direct effects that upregulate HCV RNA abundance and translation, the global de-repression of host miR-122 targets including prolyl 4-hydroxylase alpha1 (P4HA1), pyruvate kinase m2 (PKM2), and mannan-binding lectin serine protease 1 (MASP1), by viral sequestration of miR-122 provides a cellular environment fertile for liver fibrosis and the long-term oncogenic potential of HCV (56, 81).