After 10‐day, improvements in body weight, fasting plasma glucose, glucose tolerance, and insulin sensitivity. These benefits persisted after 21 days, with sustained weight loss and improved insulin resistance, alongside decreased circulating levels of cholesteryl esters, triglycerides, and ceramides. RNA‐sequence analyses showed a modulation of genes related to diabetes, obesity, fatty acid synthesis, and appetite in both the liver and hypothalamus. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.