In an AD mouse model induced by Aβ1‐42 injection, both LF‐rTMS (1 Hz) and HF‐rTMS (10 Hz) protocols enhanced cognitive performance through the activation of β‐catenin via the regulation of glycogen synthase kinase‐3β (GSK‐3β) and Tau.233. This evidence concerns the gene GSK3B and Alzheimer disease.