Examples of these models include the streptozotocin‐induced AD model110; the acrolein model, where this toxic agent induces lipid peroxidation associated with NFTs formation and Aβ polymerization111; the AAV1‐IPP2A model, which utilizes an inhibitor of protein phosphatase 2A to induce Tau hyperphosphorylation112; and models developed using high‐cholesterol diets, senescence‐accelerated mice (SAM), repeated traumatic brain injury (TBI), metallic ion alterations, and oxidative stress induction.113, 114, 115, 116. Here, MAPT is linked to Alzheimer disease.