rTMS improved cognitive function and glucose metabolism, reduced hippocampal Aβ1‐42 levels, and ameliorated oxidative stress by reducing the production of pro‐oxidative molecules while increasing the levels of antioxidants. Moreover, it alleviated neuroinflammatory response, enhanced synaptic plasticity, and reduced neuronal loss and cell apoptosis, accompanied by activation of PI3K/Akt/GLT‐1 pathway. Finally, it reversed the downregulation of NR2B levels commonly observed in AD. This evidence concerns the gene GRIN2B and Alzheimer disease.