NR4A1 and neoplasm: In addition, NKp30+ NK cells were found to promote cytolysis of B7H6+ activated T cells in nonresponding ICB patients (7), whereas tumor-infiltrating dysfunctional CD56dimCD16hi NK cells (expressing high levels of NR4A1 and inhibitory receptors and low levels of cytotoxic granules) were associated with resistance to immunotherapy (8).