Interestingly, HCC cells either away from or adjacent to immune enrichment spots showed little activation of immune regulatory signaling such as CD23, CD39, CD86, CD96, IL2, IL17 and MHC-I, in contrast to robust communications of immune signaling between the benign liver cells (Supplementary Figures S3B, S3C). The gene discussed is CD96; the disease is hepatocellular carcinoma.