On one hand, the expression of P62 stimulates the proliferation of bladder cancer cells via the activation of the Keap1-Nrf2 pathway (Li et al., 2020), and its upregulation in the early stages of tumorigenesis can induce hepatocellular carcinoma (Umemura et al., 2016). This evidence concerns the gene SQSTM1 and hepatocellular carcinoma.