Tumors, especially in low-oxygen conditions, release high levels of adenosine which stimulates the production of vascular endothelial growth factor (VEGF) by interacting with A1 AR and other receptors on surrounding cells.100 VEGF then prompts endothelial cells to grow and form new blood vessels, which extend into the tumor, enhancing its blood supply, resulting in increased supply of nutrients and oxygen facilitating the tumor's growth and spread to other parts of the body.100,101. This evidence concerns the gene VEGFA and neoplasm.