Overexpression of AC-3 increases molecules like matrix metalloproteinase 2 (MMP2), matrix metalloproteinase 9 (MMP9), and cAMP, promoting tumour growth.68,69 Inhibition of AC-3 slows tumor progression, while AC-2 is a marker for poor colon cancer outcomes. Here, ADCY3 is linked to malignant colon neoplasm.