F5 and antiphospholipid syndrome: Although relatively uncommon, thoracic aortic mural thrombi have been increasingly recognized as a cause of systemic embolism, particularly in patients with underlying prothrombotic conditions, including inherited mutations (e.g., Factor V Leiden) and acquired states (e.g., antiphospholipid syndrome, cancer), increase risk of thrombosis or inadequate anticoagulation [11].