He did not have a history of endocrinologic diseases that could cause hypertensive crisis, such as Cushing disease (which is screened for utilizing cortisol level testing), pheochromocytoma (diagnosed by checking metanephrine levels), primary hyperaldosteronism (screened for by measuring serum renin and aldosterone levels), or hyperthyroidism (requiring thyroid function testing for diagnosis); however, this required further workup, as he had never undergone diagnostic testing for these conditions [7]. Here, REN is linked to hereditary pheochromocytoma-paraganglioma.