KEGG analysis revealed that these proteins were associated with multiple biological functions, including the cell cycle (e.g., PCNA, CDK1, SMC1A, MCM6, and MCM3), endocytosis and phagosome (e.g., SEC61A1 and F1NTM6), translation elongation factor (e.g., eEF1A1, EEF4A2, and eEF1A2), ribosomal protein (e.g., RPL9, RPL11, RPL14, RPL16, RPL23, RPS3, RPS6, RPS14, PRS16 and RPS20) and virus infection (e.g., TCP1, CCT2, CCT5, CCT6, CCT7, CCT8, HSP70, and HSP90), suggesting their potential significance in FAdV-4 infection. This evidence concerns the gene SMC1A and viral infectious disease.