SLC7A11 and neoplasm: For example, p53 plays a crucial role in inhibiting tumor growth and promoting ferroptosis, in part by downregulating the expression of SLC7A11, which is achieved either by directly binding to the SLC7A11 promoter or by interacting with ubiquitin-specific peptidase 7 to reduce histone H2B monoubiquitination on the SLC7A11 promoter (39, 40).