Experimental models demonstrate that in BRAF-mutant thyroid carcinomas undergoing dedifferentiation, SNAI1/ZEB1/ZEB2 overexpression induces: (1) marked suppression of tight junction/desmosome-related genes; and (2) concurrent upregulation of intermediate filament and basement membrane components - a molecular signature validated across multiple studies (43–45). This evidence concerns the gene SNAI1 and thyroid gland carcinoma.