In addition, hypoxia mediates immunosuppression, and HIF-1α inhibits the cGAS-STING pathway through activation of anti-apoptotic genes, up-regulation of PD-L1, activation of the CD39/CD73 pathway, and up-regulation of miR25/93, thereby conferring the ability of tumor cells to evade immune surveillance (24). This evidence concerns the gene HIF1A and neoplasm.