ATG5 and neoplasm: Coloading gefitinib and shRNA‐expressing plasmid DNA targeting ATG‐5 gene (shATG‐5) into CNPs resulted in marked autophagy inhibition and suppressed tumor growth in mice bearing PLC tumors.[364] Similarly, lipid‐polycation‐HA NPs loaded with metformin and VEGF siRNA demonstrated good antitumor effects by inhibiting the mTOR pathway and activating tumor autophagy in human NSCLC H460 tumor‐bearing mice.[365]