TLR9 and neoplasm: Lin et al. reported that low concentrations of polymeric NPs promote autophagy by modulating mTOR signaling, while high concentrations can induce ACD.[287] Wang et al. engineered stimuli‐responsive CpG‐loaded nanorobots that induce autophagy‐mediated therapy for toll‐like receptor 9 (TLR9) positive cancer therapy.[288] These nanorobots were created by coself‐assembling two amphiphilic triblock polymer peptides: one with an MMP2‐cleavable GPLGVRGS motif for tumor targeting and controlled release and the other with an arginine‐rich GRRRDRGRS sequence to condense CpG payloads.