CD274 and neoplasm: This ultimately disrupts immune surveillance by natural killer cells.[65] HIF1A also induces target genes such as PD‐L1 and CCL28, promoting immune escape and tumor regrowth.[66, 67] Hypoxia is also associated with resistance to chemotherapy, as observed with doxorubicin (DOX) in human breast cancer[68] and cis‐diamine, dichloro platinum II (CDDP), and 3‐bis, 2‐chloroethyl‐1‐nitrosurea (BCNU) in brain glioma cells.[69]