ABTL0812 induces autophagy via PPARα/γ and Akt/mTOR, although it has been suggested that the cell death may be primarily autophagy independent.[294] Pevonedistat, a NEDD8‐activating enzyme inhibitor, triggers cell‐cycle arrest, apoptosis, senescence, and autophagy in many cancer cells.[417] Clinical trials in solid tumors, melanoma, acute myeloid leukemia, and myelodysplastic syndromes have shown that Pevonedistat is generally well tolerated with promising overall survival, PFS, and ORR results. This evidence concerns the gene MTOR and cancer.