Furthermore, SZP NPs induced ICD in the IRFA subcutaneous H22 model by promoting dendritic cell maturation in residual tumors, enhancing CD4+ and CD8 + T cell infiltration, and increasing anti‐tumor cytokine secretion (IFN‐γ, TNF‐α) and effector memory T cells. The gene discussed is CD8A; the disease is neoplasm.