This effect was attributed to cancer cell sensitization by countering autophagy induction caused by micelles.[279] To address challenges of premature degradation and limited clinical use of the PIK3C3/Vps34 inhibitor SAR405, Alamassi et al. demonstrated that chitosan NPs (CNPs) loaded with SAR405 or CQ effectively inhibit autophagy by blocking autophagosome‐lysosome fusion. Here, PIK3C3 is linked to cancer.