Increasing evidence suggests that adiponectin plays a protective role in the cardiovascular system; it was found that adiponectin is inversely correlated with an increased cardiovascular risk, and hypo-adiponectinemia is associated with coronary artery disease and hypertension (243), left ventricular hypertrophy (244), and a greater risk of myocardial infarction (245). This evidence concerns the gene ADIPOQ and hypertensive disorder.