Although the levels of these well-characterized biomarkers have not yet been investigated in individuals with CAH, some data are available on less extensively studied or newly identified biomarkers, including neopterin (155), osteoprotegerin (132, 156), fetuin A (157), homocysteine (158, 159), leptin (42, 57, 160–163), adiponectin (60, 164), C-reactive protein (CRP) (55, 165), hsCRP (38, 57, 135), interleukin 6 (IL-6) (55, 57, 121, 166), and circulating endothelial cells (CECs) (135) (Table 2). The gene discussed is LEP; the disease is congenital adrenal hyperplasia.