HCRT and Sepsis: However, Ogawa and colleagues40 reported that peripherally administered orexin A improved survival in a murine model of sepsis by mainly acting in the medullary raphe nucleus through OX2R. A preliminary follow-up study by the same authors found reduced cerebrospinal fluid orexin concentrations in rats and patients with systemic inflammation, supporting the hypothesis that orexin treatment may enhance recovery from sepsis.41