PRKN and infection: Surprisingly, the knockdown of Atg5 in epithelial cells led to a decrease in the expression of PINK1, Parkin, and PHB2 upon P. aeruginosa treatment, implying that the loss of Atg5 not only disrupts mitophagy by impeding autophagosomal formation but also inhibits both ubiquitin‐dependent and receptor‐mediated mitophagy pathways during infection (Figure 5B,C).