For example, the dysregulation of signaling pathways, including TLR, JAK–STAT, PI3K–AKT, and NF‐κB, is closely associated with chronic inflammatory diseases such as rheumatoid arthritis (RA) and atherosclerosis, as well as with the immunosuppressive effects mediated by tumor‐associated macrophages (TAMs) [4, 5]. This evidence concerns the gene AKT1 and rheumatoid arthritis.