SOAT1 and neoplasm: For example, the dysregulation of signaling pathways, including TLR, JAK–STAT, PI3K–AKT, and NF‐κB, is closely associated with chronic inflammatory diseases such as rheumatoid arthritis (RA) and atherosclerosis, as well as with the immunosuppressive effects mediated by tumor‐associated macrophages (TAMs) [4, 5].