IL‐12‐hyperexpressing monocytes exhibit suppressed phosphorylation of STAT3 (p‐STAT3) and diminished c‐Myc signaling activity, a molecular reprogramming that drives macrophage polarization toward proinflammatory M1 states while exerting tumor‐suppressive effects on HCC progression [224]. The gene discussed is STAT3; the disease is hepatocellular carcinoma.