The M2‐polarized TAM population in TME demonstrates bifunctional capacity: First, through immunosuppressive cytokine secretion (notably IL‐10/TGF‐β), they establish an immune‐evasive milieu; second, via sustained production of proangiogenic mediators (VEGF) and MMPs, they actively potentiate CCA growth, local infiltration, and distant metastasis. Here, VEGFA is linked to cholangiocarcinoma.