Th2 differentiation dominates in patients with AD, and therefore production of cytokines IL-4, IL-5, IL-13, and IL-31 were induced, which then facilitate B cells to produce immunoglobulin E (IgE), and thus Th1 differentiation was suppressed (Eyerich and Novak, 2013). The gene discussed is IGHE; the disease is Alzheimer disease.