ESR1 and brain ischemia: Liu H Found that Rut can enhance Erα ERβ, BDNF, The levels of nerve growth factor (NGF), tropomyosin receptor kinase A (TrkA), TrkB and cyclic adenosine monophosphate response element binding protein (p-CREB) in ovariectomized rats were measured and the cerebral ischemia/reperfusion injury in ovariectomized rats was improved.