PODXL and coronary artery disorder: In addition, miR-34c-5p derived from extracellular vesicles of activated platelets (PLT-EVs) also attenuates inflammatory responses in HCAEC through inhibition of the podocalyxin (PODXL) and P38 MAPK signaling pathways, thereby preventing the development of CAD (Bai et al., 2022).