RAC1 and neoplasm: Analyses of UALCAN and kmplotter datasets revealed that lower DOCK4 expression in LUAD samples is associated with unfavorable patient outcomes, consistent with previous reports (Yu et al., 2020)。Functionally, DOCK4 has been reported to regulate tumor cell migration, invasion, and metastasis in LUAD, primarily through Rac1 activation under TGF-β/Smad signaling (Yu et al., 2015).