DOCK4 and neoplasm: Similar to other DOCK family members such as DOCK2—which exhibits either tumor-suppressive or tumor-promoting roles depending on the specific tumor context and immune microenvironment—DOCK4 is involved in diverse signaling pathways in LUAD, including MYC signaling and DNA repair (Wu et al., 2017; Hu et al., 2019; Zeng et al., 2021).