Mechanistically, DCM progression was associated with upregulated pyroptotic markers: myocardial tissues and HG-treated NMCMs showed elevated expression of cleaved caspase-1, NLRP3, phospho-NF-κB, and GSDMD compared to controls, accompanied by increased pyroptosome formation. This evidence concerns the gene CASP1 and familial dilated cardiomyopathy.