Recent studies have highlighted the significant potential of TCMFG in treating complex diseases, such as inflammation, tumors, metabolic disorders, fibrosis, and orthopedic conditions like osteoarthritis and osteoporosis, by modulating signaling pathways such as TLR4/NF-κB, MAPK, NLRP3 inflammasome, PI3K/Akt/mTOR, Wnt/β-catenin, and TGF-β/Smads. This evidence concerns the gene AKT1 and osteoarthritis.