A model based on dual-task gait, smooth pursuit, prosaccade, and anti-saccade achieved the best area under the receiver operating characteristics curve (AUC) of 0.987 for CI detection. In contrast, combined with phosphorylated tau 181 (p-tau181), the model discriminated mild cognitive impairment from controls with an AUC of 0.824. This evidence concerns the gene MAPT and Cognitive impairment.