In cancers such as THYM, UVM, MESO, PRAD, COAD, READ, KICH, UCS, LGG, OV, KIRP, LIHC, BRCA, BRCA-LumA, BRCA-LumB, and SARC, ADM exhibited strong positive correlations with almost all immune-related genes, including BTLA, BTN2A1, CD160, CD200, CD200R1, CD209, CD226, CD244, CD276, CD28, CD40, CD48, CD86, CTLA4, PVR, TIGIT, TNFRSF18, TNFRSF9, TNFSF14, TNFSF18, CD27, CD274, CD70, CD96, ICOS, TNFRSF25, TNFRSF4, TNFSF9, TNFSF15, HHLA2, TNFRSF14, CD47, and PDCD1. This evidence concerns the gene ICOS and cancer.