Furthermore, the correlation heatmap depicting the relationship between ADM expression and three methyltransferase genes (DNMT1, DNMT3A, DNMT3B) in multiple cancer types revealed weak correlations, with small correlation coefficients, indicating that ADM expression was not strongly linked to the activity of these methyltransferase genes at pan-cancer level (Figure 4C). This evidence concerns the gene DNMT3A and cancer.