Abnormalities in the VWF protein due to VWF mutations would result in von Willebrand disease (VWD), a common inherited bleeding disorder with an estimated prevalence from 1 per 1000 to 1 per 100 population, while the real prevalence is still not well established yet [[8], [9], [10]]. Here, VWF is linked to von Willebrand disease (hereditary or acquired).