P. acnes significantly increases in GC tissues infected with H. pylori, activating the TLR4/PI3K/Akt signaling pathway, inducing polarization of M2-type tumor-associated macrophages (TAMs), and promoting the secretion of immunosuppressive factors IL-10 and CCR-2 (Li et al., 2021c). The gene discussed is IL10; the disease is neoplasm.