From a collection of 15 studies (Carapito et al., 2019; Latchman et al., 2020; Córdova-Fletes et al., 2015; Lu et al., 2022; Phetthong et al., 2021; He et al., 2024; Sheth et al., 2023; Alqahtani et al., 2023; Zhou et al., 2022; Deng et al., 2022; Valind et al., 2021; Bartolomaeus et al., 2023; Brea-Fernández et al., 2022; Schluth-Bolard et al., 2019; Kruidenier et al., 2025) describing patients with mutations in ZMIZ1 and diagnosed NDDs or developmental delay, we selected for this study 36 unique de novo mutations (35 SNVs and 1 deletion) in the ZMIZ1 protein coding region. The gene discussed is ZMIZ1; the disease is Global developmental delay.