DHCR7 and hepatocellular carcinoma: Here we evaluated the role of DHCR7 in the pathogenesis of MetALD and HCC in alcohol-injured wild-type (WT) and Dhcr7+/– mice and determined that suppression of DHCR7 ameliorates hepatic steatosis, inflammation, and fibrosis and reduces the incidences of alcohol-induced HCC.