CHRNA7 and Alzheimer disease: Expanding on this, recent findings indicate that Aβ1–42 forms a high-affinity, stable complex with the α7 nicotinic acetylcholine receptor (α7 nAChR) in vitro and co-localizes with neuritic plaques in the AD brain, suggesting a direct modulatory effect on cholinergic neurotransmission (Wang et al., 2000).