Since resident CD8+ memory T lymphocytes play a critical role in long-term protection against malaria [74], [75], and the WHO's target of 75 % protection lasting more than two years underscores the importance of including not only the most immunogenic but also the most conserved epitopes in the C-terminal domain of CSP, this illustrates the pivotal role of computational vaccinology and immuno-informatics. This evidence concerns the gene DNAJC5 and malaria.