Respiratory rate (OR = 1.058, 95% CI: 1.035–1.081), weight (OR = 0.483, 95% CI: 0.340–0.686), C-reactive protein (CRP) (OR = 1.142, 95% CI: 1.028–1.268), neutrophil (NEU) (OR = 1.384, 95% CI: 1.232–1.555), hemoglobin (HGB) (OR = 0.989, 95% CI: 0.979–0.999), uric acid (UA) (OR = 1.006, 95% CI: 1.002–1.010), and blood urea nitrogen (BUN) (OR = 1.230, 95% CI: 1.058–1.431) were identified as independent risk factors for neonatal severe pneumonia. The gene discussed is CRP; the disease is pneumonia.