Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) screening data from the project score database identified CTNNB1 as a key gene in APC‐dependent CRC cell lines, whereas Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) and B‐Raf Proto‐Oncogene, Serine/Threonine Kinase (BRAF) were predominant in KRAS/BRAF‐dependent lines (Figure 1A). This evidence concerns the gene MARK2 and colorectal carcinoma.