Sepsis is a significant public health concern with a case fatality rate of around 25% in children.1–3 Various biomarkers have been studied for diagnosing, guiding management decisions, and informing prognosis for patients with sepsis.4 Certain biomarkers, including C-reactive protein and procalcitonin, have been the most frequently studied and proposed to have a role in assisting with clinical evaluation for sepsis.5 This evidence concerns the gene CRP and Sepsis.