In uremic pruritus, it is probably secondary to CKD‐related xerosis, higher skin‐surface pH, and gut microbiota imbalance, with an immune milieu marked by elevated interleukin (IL)‐2, IL‐6, IL‐31, histamine, and altered monocyte subsets [23, 24, 25, 26, 27]. Here, IL31 is linked to chronic kidney disease.