In uremic pruritus, it is probably secondary to CKD‐related xerosis, higher skin‐surface pH, and gut microbiota imbalance, with an immune milieu marked by elevated interleukin (IL)‐2, IL‐6, IL‐31, histamine, and altered monocyte subsets [23, 24, 25, 26, 27]. This evidence concerns the gene IL6 and chronic kidney disease.