MC4R and Polyphagia: Hyperphagia has been observed within the first few years of life in patients who have variants in GNAS, LEP, LEPR, MC4R, NCOA1, PCSK1, POMC, and SH2B1 (including 16p11.2 deletions) [3, 10, 12, 25, 27, 28, 35, 49, 52, 61, 62].