This pathway comprises key molecules, receptors, and processing enzymes that are encoded by genes such as GNAS, LEP, LEPR, MC4R, PCSK1, POMC, SH2B1, and SIM1, as well as key Bardet‐Biedl syndrome (BBS)‐associated genes [2, 22, 23, 24]. This evidence concerns the gene SH2B1 and Bardet-Biedl syndrome.