Studies have identified infectious agents in 75% of pediatric patients with reactive thrombocytosis.14-15Inflammation promotes proplatelet production and hepatic thrombopoietin synthesis in megakaryocytes by increasing IL-6 secretion, possibly leading to thrombocytosis and potential thrombosis.17-19 In this study, in line with the literature, platelet levels were higher in patients with culture growth and proven infection compared to patients without growth. The gene discussed is IL6; the disease is infection.