Additionally, ESRP1 plays a crucial role in the chemoresistance of multiple cancers and functions as a novel drug resistance marker molecule and a potential therapeutic target [17, 23, 24].These findings may highlight the clinical significance of ESRP1 in tumor progression and metastasis and offer a potential predictive system for evaluating outcomes in patients with gastric cancer. The gene discussed is ESRP1; the disease is gastric cancer.