Interestingly, analysis of DeepSeek (https://chat.deepseek.com/) indicated that Drp1 was significantly upregulated in ESCC tissues and played a crucial role in the progression of ESCC by activating several related signaling pathways, including PI3K/AKT/mTOR, MAPK/ERK, Wnt/β-catenin, and Hippo/YAP. The gene discussed is MAPK1; the disease is esophageal squamous cell carcinoma.