CHEK2 and non-small cell lung carcinoma: Similarly, in non-small cell lung carcinoma (NSCLC), hyperthermia promotes caspase-3-dependent apoptosis through the ATM-Chk2-Cdc25C pathway and enhances the expression of p21 and Bax mRNA in A549 cells, inhibiting cell growth [10].These findings indicate hyperthermia’s potential as an effective anticancer therapy with distinct molecular mechanisms.