This smart construct demonstrated (1) 84% NETs degradation efficiency via substrate peptide cleavage and DNase I activation; (2) 3.2-fold greater tumor cell internalization through Tat peptide mediation; and (3) synergistic suppression of primary tumor growth (58% reduction) and distant metastases (73% inhibition) in triple-negative breast cancer models [164] (Fig. 4A). The gene discussed is TAT; the disease is neoplasm.