The CORTAHF (Effect of Short-Term Prednisone Therapy on CRP Change in Emergency Department Patients with Acute Heart Failure and Elevated Inflammatory Markers) trial showed that 7 days of prednisone therapy significantly reduced hsCRP (adjusted geometric mean ratio of 0.30 in prednisone group vs 0.40 in placebo, p = 0.0498) in acute HF patients with elevated hsCRP at baseline. This evidence concerns the gene CRP and hydrops fetalis.