GPNMB and neoplasm: Compared to GPNMB-, GPNMB+ cells exhibited significantly longer latency of tumor formation, measured by either time to palpability (Fig. 8K, Appendix Fig. S9J) or time to tumor resection (volume of ~0.3 cm3) (Fig. 8L; Appendix Fig. S9K) but earlier latency of lymph node invasion (Fig. 8M; Appendix Fig. S9L and Appendix Table S2), consistent with their less proliferative and more invasive phenotype.