This signature highlights a potential link between the quiescent state and specific cellular programs, as several top-ranked markers (PRRX1, LUM and SPARC) significantly overlapped with a previously described signature for a “mesenchymal-like” state of melanoma metastatic initiating cells (Karras et al, 2022) (Appendix Fig. S9A). The gene discussed is SPARC; the disease is melanoma.