Additionally, they play critical roles in reprogramming the tumor immune microenvironment (TIME), influencing T cell trafficking (H19), MDSC differentiation (PVT1, RUNXOR, Lnc57Rik), Treg-mediated immunosuppression (SNHG16), and promoting immune cell-cancer cell interactions (LNMAT1, JHDM1D-AS1). This evidence concerns the gene PVT1 and neoplasm.