For instance, silencing lncRNAs such as MEG3, FTX, and MIAT in tumor-infiltrating myeloid or T cells, or enhancing expression of pro-inflammatory lncRNAs like NEAT1 or MIR17HG in T cells, may reduce immunosuppression, promote infiltration, and enhance activation of anti-tumor immunity. The gene discussed is MEG3; the disease is neoplasm.